Nalfurafine Combined with Standard‐of‐Care Diuretics Increases Diuresis and Limits Electrolyte Losses

Electrolyte disturbance with diuretics and ACEIs.

Evidence • The ALLHAT substudy1 (n = 19 731 with normal baseline K levels) found the following results at 1 year. -Overall, 3.5% of those taking chlorthalidone (12.5 to 25 mg), 0.2% of those taking lisinopril (10 to 40 mg), and 0.3% of those taking amlodipine (2.5 to 10 mg) had K levels less than 3.2 mmol/L; 1.2% of those taking chlorthalidone, 3.6% of those taking lisinopril, and 1.9% of those...

Salt and Water Losses in Diuretin Diuresis and Their Relation to Serum Non-protein Nitrogen and Electrolyte Concentrations

The losses of sodium, potassium, chloride, nitrogen, and water following the administration of diuretin to rabbits over 5 to 9 day periods together with the changes in serum concentrations of sodium, chloride, N. P. N., and total protein occurring simultaneously with these losses are described. The circumstances responsible for the presence of azotemia in the animals were investigated in partic...

The effects of the loop diuretics furosemide and torasemide on diuresis in dogs and cats.

Torasemide is a new loop diuretic that combines the effects of furosemide and spironolactone. There are no reports on the effects of torasemide in cats and dogs. This study compared the diuretic effects of furosemide and torasemide in cats and dogs. Cats with pressure overload cardiac hypertrophy were given oral placebo, torasemide 0.3 mg/kg, or furosemide 1 mg/kg or 3 mg/kg. Control and mitral...

Congestive heart failure; variations in electrolyte metabolism with salt restriction and mercurial diuretics.

Recent Developments in Oral Replacement of Fluid and Electrolyte Losses

Oral rehydration therapy (ORT), using a solution of glucose and three salts (ORS) is an elegant and deceptively simple therapeutic technology, to treat or prevent dehydration from diarrhea, that stood the test of time over the past 25 years of use. It contributed substantially to the dramatic global reduction in mortality from diarrheal diseases during this period (1). However, its use does not...